Sunday, April 18, 2010

The psychology of erectile dysfunctio

The body is really just a complicated machine with blood pumping round the plumbing system and muscles moving the bones around. Any machine can break down and a mechanic can fix it. But think about a car. You can repair damage but it still takes someone to drive it. Sex is more than plumbing. You have to be in the mood and find the partner attractive. If, for some reason, you stop being interested in sex, the driver may never take the car out of the garage. Why might this happen? Some men suffer performance anxiety.

They have had bad experiences and no longer want to risk their self-esteem. Others may become depressed and find their libido failing. Alternatively, you may just have fallen out of love with this partner and now avoid sexual contact with her. When the mind is so important to the proposed activity, it is surprisingly easy to create sexual difficulties for yourself. Sex is just something that happens naturally, but what is natural can become wrapped up in fear, shame, humiliation, guilt and other emotions that get in the way. If this happens, no drug can or will solve the problem. Viagra just a plumber. Unless you want to resume sexual activity, the pipes will remain unused.

All the medical evidence shows you have to treat the other problems before treating the erectile dysfunction. For example, if you are depressed and lose interest in sex, you have to treat the causes of the depression. Ironically, erectile dysfunction is one of the side effects of many drugs used to treat depression. So, clearing the mind of its problems comes first, followed by giving up the antidepressants. But then starting viagra may not be the answer because you need a willing partner who is going to be supportive. There are social problems to deal with after the medical issues are resolved.

It is the easiest thing in the world to say, "You have to remember how much fun sex is." But when it comes to trusting yourself to give and receive pleasure, you suddenly confront the risks to your self-confidence. What happens if something goes wrong this time? If the relationship is strong and your partner wants you to succeed, you can find restarting sexual activity very rewarding. A couple working to solve a problem together often emerges stronger. But if the relationship is weak, overcoming the fear of failure is a big hurdle. Remember, you have no chance of overcoming the fear unless you take a chance. If you take the risk, the rewards are there for the taking.

The best way forward is through cognitive behavioral therapy. This teaches you ways to build your confidence. Unfortunately, there are not enough trained therapists and not all medical insurance policies cover the cost of treatment. This brings viagra back into play. This drug gives otherwise healthy men the best possible chance of a successful sex life. Doubt can be a problem but, if you believe in viagra enough, it will help rebuild the enjoyment in sex. As you find more success, your confidence will improve and you can get back to how it was when you were younger.

Natural Tramadol produced within our brain

A recent experiment has shed more light on the concept of human body's natural pain relief system. Scientist have analyzed the activity of chemicals in the braains of study participants who were subjected to sustained pain and have come to new concepts of subjective pain sensations and how the body deals with pain.

The results of the study have confirmed that there's a connection between what people feel when experiencing pain and what happens with their brain chemical balance at the same time. This will definitely help find better pain relief solutions in the future as the concept of pain itself gains new dimensions of understanding. Researchers have indicated the crucial role of endorphins (naturally produced opioids) in blocking certain receptors in the brain and thus restricting pain signals from spreading throughout the system.

Duding the test the subject had to sustain 20 minutes of jaw muscle pain. The readings of brain chemical activity indicated an increased production of endorphins with the start of pain sensations. And when the substance was in abundance the subject reported decline in unpleasant sensations of pain, saying it has become less intense than previously.

The regions in the brain that were already known for their role in emotional and affective responses have indicated the largest increased in endorphin production. This fact gives scientists a better understanding of how brain chemistry and emotional behavior are closely related.

Endorphins being quite similar to synthetic opioids such as Tramadol target special types of mu opioid receptors in the brain and thus block pain signals. But the distribution of these receptors in the brain also plays an important role in subjective pain sensations and the effect we know as the pain threshold.


Researchers have found that the highest concentration of mu opioid receptors is found in the exact areas of the brain that are responsible for emotions and feelings.


More interesting discoveries were made when comparing the chemical activity between different test subjects. Having individual peculiarities in location and concentration of pain-receiving mu opioid receptors, test participants have also displayed various levels of endorphin production, which was directly related to pain ratings they have reported. If some people have rated their pain sensations as low with abundant production of chemicals that delivered nearly the same results as painkiller medications like Tramadol hcl, others had very strong pain sensations due to the low levels of endorphins produced in the brain. This explains the difference in natural pain threshold level each of us has.

Does this mean that we don't have to buy Tramadol anymore and have to rely on our natural painkiller system? Of course, no. There are different types of pain that are very hard to withstand even if you have a high level of pain tolerance.

However, this study will definitely help scientists understand the effects of the natural pain-relief system and improve painkiller medications in order to gain better effectiveness without competing the natural abilities of the body to control pain sensations. Who knows, maybe there won't be a need in medications at all if we learn how to control our own abilities. But until then we will still use drugs to make the pain go away.

How do car insurance companies calculate the premium rates?

The business of insurance is called underwriting. The company enters into a contract (called a policy) and agrees to indemnify a group of people like you against defined losses. So it uses some heavy duty math to work out the probability of the losses being incurred. It's called risk assessment and relies on a complicated use of statistics. For vehicle insurance, the companies collect the details from every reported traffic accident in the US looking at the age, sex and occupation of the driver, the make and model being driven, the time of day, the road conditions, and the extent of the damage. The insurers share the information on the current costs of replacement parts and the labor to fit them.

They also manage to talk the health insurance companies into sharing their current costs on medical treatment for those injured in traffic accidents. With all this information, they can make good estimates of the cost of loss, i.e. the total amount they may have to pay out if they insure, say, 100,000 drivers. They take this estimate, add the cost of running the insurance company and a profit margin. This total is then divided between all the 100,000 as their premiums. Some companies divide the total equally so the good drivers subsidize the bad. But the majority adjusts the individual amounts based on the driver's safety record. That way, each policy holder pays more or less depending on how well he or she drives. This is more fair.

But, to cut costs, some insurance companies make more general assumptions about the likelihood of losses. Instead of personalising the risk assessment, they focus the assessment on generalities. The most common is the use of the zip code. In some areas of a town or city, there are higher levels of vehicle theft and vandalism. Some areas have more people driving while intoxicated or impaired through drugs. Because of the design of the local road system, there may also be a higher number of accidents. The insurers therefore charge everyone living in those areas a higher premium. Apart from the unfairness at an individual level, some lawyers believe it is active discrimination because many of the zip code areas loaded with higher premiums have higher concentrations of particular racial or ethnic groups. California has formally prohibited insurance companies from using zip codes, credit scores and other factors not directly relevant to the assessment of driver safety. In those states, insurers continue to trade and make a profit. It has not been the end of the world they predicted.

So, depending on the US state in which you live, your premium may either be calculated based on your personal driving record, or it may be based on your zip code and credit score. Either way, the task of finding the cheapest auto insurance remains the same. You have to shop around the companies licensed to sell policies in your state and find the best deal. If there is active competition between the insurers, the premiums will be lower and you will find cheap auto insurance without too much difficulty. But if the state is unregulated and insurers do not compete, it will be more difficult to find a cheap policy.

All about health insurance savings

If you have been asking questions about healthcare coverage you have definitely heard about health savings accounts (HSAs). Some people advocate that they are the next step in the domain of health coverage, while the others believe that only healthy and rich citizens can benefit from such plans. Before answering these questions it is better to learn what HSAs are in essence and how do they work.

What is a HSA?
A typical health savings account is comprised of two elements:

1) Savings account with interest bearing:
- Yearly deposits of up to $2,900 ($5,800 in case of a family) introduced to the savings account are to be taxed. The money deposited will usually roll over on a yearly basis. However, the money you withdraw from the account for healthcare purposes are tax-free. So are any withdrawals after you officially retire.

2) Healthcare coverage plan with a high deductible
- The minimum deductible amount should be not less than $1,100 ($2,200 in case of a family). That is the amount of money to be paid out-of-pocket before getting the actual benefits.

- When the annual deductible is paid the actual coverage kicks in. You will have to pay all the specified co-insurance and the plan will cover all that remains.

- The overall amount of money to be paid out-of-pocket is limited to $5,600 ($11,200 in case of a family). In other words, after you have spent $5,600 on healthiness services your insurance company will pay for all health costs exceeding that amount.

What are the pros of health savings accounts?
- Because of the fact that any money withdrawn for healthcare use is not taxed, HSAs are a good way of saving more money in your pocket.
- In case you keep the funds without withdrawing them from the account you will have more money after you retire. And since you can freely withdraw the money for any reason after you turn 65 it is a good additional source of retirement money.
- Health insurance plans with higher deductibles have lower premiums than typical plans.
- HSAs don't depend on your working place and you will keep it the same no matter what.

What are the cons of healh savings accounts?
- Those who have substantial needs in healthcare services will find little use in HSAs since they provide main benefits when the money is kept in the account for an extended period of time.
- People with serious health issues will find it hard to get high-deductible insurance plans, especially if they were already denied of typical plans.
- Some HSAs have additional fees that in sum can make the plan quite costly for the customer.
- Because of high out-of-pocket expenses people tend to go without care, which usually results in complications and more serious and expensive health concerns.

Will a HSA be useful for me?
In case you have no serious health problems and are able to pay the required out-of-pocket expenses than HSAs will definitely be a good option for you. However, you must understand that HSAs require you to be more conscious about your medical costs and the coverage provided by these accounts is much less comprehensive and diverse than with typical health insurance plans. Having an active position in managing own healthcare is a must with HSAs, so if you're not ready for that then it will be not of a much use to you.

Saturday, April 17, 2010

Research into Valium and the risk of dependence continues

Even though there have been a wide range of drugs on the market for many years derived from the benzodiazepines, the research into their character and performance continues apace. This does not mean the drugs are any less safe than when they were first introduced more than fifty years ago. It simply reflects the genuine desire to improve their performance. The key problem remains the need to limit time. No matter how effective the drug may be, there is a real risk of psychological or physical dependence if people take the drug at too high a dosage or over too long a period of time. Why is this? The reason is that, in the same way as cannabis and the more powerful heroin affect the chemistry of the brain, so the benzodiazepines offer chemical rewards to the pleasure centers of the brain. Researchers in the US and Switzerland have recently released the results of study into the precise mechanism at work. We have long known that the benzodiazepines affect the level of the neurotransmitter called Gamma-Aminobutyric Acid (GABA). As the amount of GABA increases, this triggers the release of dopamine, which is a so-called gratification hormone. It makes us feel good. It rewards us for taking the pill and encourages us to repeat the activity. In this, the benzodiazepines are working in exactly the same way as the addictive street drugs. However, the latest research pinpoints a specific receptor in the GABA's chemical structure. For the technically minded, this is called the Alpha1 Sub-Unit of the GABA Type A Receptor.

You are now all saying, "So what?" In fact, this is a very big "what". For the last fifty and more years, we have had to limit our uses of some very valuable drugs. Suppose we can tweak the benzodiazepines so they bind to Alpha2, Alpha3, or to the Type B Receptor. This linkage may produce the result we want without triggering the release of the dopamine. If no dopamine is released, we have a non-addictive version of the benzodiazepines. That is not just for the anti-anxiety and antidepressive drugs. It also includes useful drugs used for appetite suppression, and so on.

Over the last ten years, there has been new research into producing the next generation of valium. Early results in manipulating Alpha2 and Alpha3 have not yet proved a success, but Merck and the other pharmaceutical companies are investing increasing amounts of money in the push to modify the chemistry of the current anti-anxiety and panic disorder drugs to produce the same effect but without the problem of dependence. Until this work delivers clinical trial results sufficient to satisfy the FDA, we will continue to rely on valium - a drug that has consistently proved itself effective to control anxiety and worry, and eliminate the threat of panic attacks. But, of course, with the condition that we do not exceed the dosage instructions given to us by doctors and pharmacists. The risk of dependence is manageable but real. If we do abuse this drug, we end up in much the same position as if we had become addicted to heroin or one of its derivatives. Once the brain's reward system has been activated, it produces increasingly unpleasant withdrawal symptoms if we stop taking the drug. Many people find they lack the willpower to fight through the symptoms and stay free. Let us hope the researchers can tweak valium so we can have the benefits without this risk.

Research into Valium and the risk of dependence continues

Even though there have been a wide range of drugs on the market for many years derived from the benzodiazepines, the research into their character and performance continues apace. This does not mean the drugs are any less safe than when they were first introduced more than fifty years ago. It simply reflects the genuine desire to improve their performance. The key problem remains the need to limit time. No matter how effective the drug may be, there is a real risk of psychological or physical dependence if people take the drug at too high a dosage or over too long a period of time. Why is this? The reason is that, in the same way as cannabis and the more powerful heroin affect the chemistry of the brain, so the benzodiazepines offer chemical rewards to the pleasure centers of the brain. Researchers in the US and Switzerland have recently released the results of study into the precise mechanism at work. We have long known that the benzodiazepines affect the level of the neurotransmitter called Gamma-Aminobutyric Acid (GABA). As the amount of GABA increases, this triggers the release of dopamine, which is a so-called gratification hormone. It makes us feel good. It rewards us for taking the pill and encourages us to repeat the activity. In this, the benzodiazepines are working in exactly the same way as the addictive street drugs. However, the latest research pinpoints a specific receptor in the GABA's chemical structure. For the technically minded, this is called the Alpha1 Sub-Unit of the GABA Type A Receptor.

You are now all saying, "So what?" In fact, this is a very big "what". For the last fifty and more years, we have had to limit our uses of some very valuable drugs. Suppose we can tweak the benzodiazepines so they bind to Alpha2, Alpha3, or to the Type B Receptor. This linkage may produce the result we want without triggering the release of the dopamine. If no dopamine is released, we have a non-addictive version of the benzodiazepines. That is not just for the anti-anxiety and antidepressive drugs. It also includes useful drugs used for appetite suppression, and so on.

Over the last ten years, there has been new research into producing the next generation of valium. Early results in manipulating Alpha2 and Alpha3 have not yet proved a success, but Merck and the other pharmaceutical companies are investing increasing amounts of money in the push to modify the chemistry of the current anti-anxiety and panic disorder drugs to produce the same effect but without the problem of dependence. Until this work delivers clinical trial results sufficient to satisfy the FDA, we will continue to rely on valium - a drug that has consistently proved itself effective to control anxiety and worry, and eliminate the threat of panic attacks. But, of course, with the condition that we do not exceed the dosage instructions given to us by doctors and pharmacists. The risk of dependence is manageable but real. If we do abuse this drug, we end up in much the same position as if we had become addicted to heroin or one of its derivatives. Once the brain's reward system has been activated, it produces increasingly unpleasant withdrawal symptoms if we stop taking the drug. Many people find they lack the willpower to fight through the symptoms and stay free. Let us hope the researchers can tweak valium so we can have the benefits without this risk.

Friday, April 16, 2010

The easiest way to understand how an insurance policy works is to think about gambling. You are about to drive your vehicle out on to the public roads and you make a bet with the insurance company. If you can do this without having an accident, you lose the premium. If you have an accident, the insurance company pays your losses. So, as with a field of horse about to set off round the track, the bookmakers check the records of each horse. How many times has it run and placed. This gives them a basis on which to set the odds. In theory, everyone has access to the same information so you decide whether to place the wager depending on the fairness of the odds quoted. Well, it's exactly the same with drivers. The insurers make a risk assessment of you as a driver. What make and model are you driving? How many miles a year do you drive? How many years of experience? How many tickets and claims? This profiling gives them the odds of an accident and the company sets the premium rate to quote you. You also know your own track record and have a good basis on which to decide whether to pay the premium.


Unlike a conventional bet, you can decide to self-insure a part of the potential liabilities. This is done through the so-called deductible where you pay the nominated amount before the insurer has to contribute. So if the claim against you is for $800 and you have a deductible of $1,000, you pay the whole of the $800. But if the claim is for $1 million, you only pay $1,000 and the insurance company loves you like a brother. The majority of traffic accidents are minor fender benders and the repair costs are usually low. If no-one is injured, self-insurance is a cost-effective option, i.e. the amount you save on the premium covers the likely payments of claims. But you should consider the issues carefully before accepting the maximum deductibles. Suppose you have a bad run of luck and, in the space of a year, you are involved in three accidents where the claims exceed the deductible. Now you have to find the deductible multiplied by three as a cash sum and your premiums will go up because you have proved yourself a bad risk. Can you afford the pay this lump sum without breaking the bank? Given your premiums are going to rise, do you still want to pay the maximum deductibles in the future?


Planning is all about the worst case scenarios and hoping for the best. There are good discounts for increasing the deductible. There are also good discounts for insuring more than one vehicle or combining both auto insurance with home insurance. Because you cannot guarantee you will never have accidents, you should decide what discounts you can find and how much you are prepared to pay if the worst happens. Do not simply buy the cheapest auto insurance you can find. In many cases, these policies do not give a good value-for-money cover against liabilities. Shop around and buy the policy that gives you the best protection at a price you can afford.